Gamma-aminobutyric acid (GABA): a para- and/or autocrine hormone in the pituitary.

نویسندگان

  • A Mayerhofer
  • B Höhne-Zell
  • K Gamel-Didelon
  • H Jung
  • P Redecker
  • D Grube
  • H F Urbanski
  • B Gasnier
  • J M Fritschy
  • M Gratzl
چکیده

ARTUR MAYERHOFER,* BARBARA HÖHNE-ZELL,* KATIA GAMEL-DIDELON,* HEIKE JUNG, PETER REDECKER, DIETRICH GRUBE, HENRYK F. URBANSKI, BRUNO GASNIER, JEAN-MARC FRITSCHY, AND MANFRED GRATZL* *Anatomisches Institut der Universität München, Germany; Zentrum Kinderheilkunde und Humangenetik der Medizinischen Hochschule and Abteilung Anatomie I der Medizinischen Hochschule Hannover, Germany; Division of Neuroscience, ORPRC-OHSU, Beaverton, Oregon 97006, USA; CNRS UPR 1929, Institut de Biologie Physico-Chimique, Paris, France; and Institute of Pharmacology, University of Zürich, CH-8057 Zürich, Switzerland

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P146: Gamma Aminobutyric Acid (GABA) and its Alterations in Stress

Gamma aminobutyrate (GABA) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. Mechanisms by which GABA may facilitate these responses to stress are metabolic and/or mechanical disruptions. Environmental stresses increase GABA accumulation through cytosolic acidification, induce an acidic pH-dependent activation of glutamate...

متن کامل

An autocrine role for pituitary GABA: activation of GABA-B receptors and regulation of growth hormone levels.

There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs. Examples of such functions are documented in the pancreas, but recent results suggest that GABA may act in a similar way in the pituitary, in which GABA receptors are expressed and pituitary growth hormone (GH) cells provide a source ...

متن کامل

Relaxatory Effect of Gamma-Aminobutyric Acid (GABA) is Mediated by Same Pathway in Diabetic and Normal Rat Mesenteric Bed vessel

Objective(s) Diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. Vasorelaxant agents may have a role in control of diabetic cardiovascular complications. Gamma aminobutyric acid (GABA) has demonstrated to cause vasorelaxation. The present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of e...

متن کامل

Gamma-aminobutyric acid up-regulates the expression of a novel secretogranin-II messenger ribonucleic acid in the goldfish pituitary.

An RNA-arbitrarily primed PCR differential display strategy was used to identify candidate genes in the pituitary that are up-regulated by endogenously activated gamma-aminobutyric acid (GABA) systems that may also be involved in the control of reproduction. Goldfish were injected with the GABA metabolism inhibitor gamma-vinyl-GABA (GVG), known for its high efficiency to specifically increase e...

متن کامل

Effect of Curcumin on the Hypothalamus Levels of the Potent Inhibitory Neurotransmitter ,Gamma aminobutyric acid

Background: There are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. According to several studies, elevated serum levels of gamma-amino butyric acid (GABA), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. The purpose of this research was to estimate the effects of curcumi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

دوره 15 6  شماره 

صفحات  -

تاریخ انتشار 2001